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  • Al fresco dining at night in Minneapolis, Minnesota
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    Minneapolis and St. Paul, Minnesota

  • Great River Road Ship's Wheel Sign in Potosi, Wisconsin
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    Potosi, Wisconsin

  • Steamboat on the Mississippi River in LeClaire, Iowa
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    LeClaire, Iowa

  • Red-brick street in Hannibal, Missouri
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    Hannibal, Missouri

  • Cardinals Major League Baseball game in St. Louis, Missouri
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    St. Louis, Missouri

  • Beale Street lights at night in Memphis, Tennessee
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    Memphis, Tennessee

  • Streetlit roadway by the Mississippi River in Natchez, Mississippi
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    Natchez, Mississippi

  • City street in the French Quarter in New Orleans, Louisiana
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    New Orleans, Louisiana

Paddle wheel boat on the Mississippi River
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Going Down the Great River Road

  • Route distance:
    2,254 km
  • Suggested Time:
    1-2 weeks

Follow the Mississippi River from Minnesota to Louisiana

The beating heart of America lies in its great middle. The pulsing artery of the nation is the Mississippi River and following its path by car provides a unique and unforgettable view of this nation. This is the river that sparked the imagination of one of the USA’s finest authors, Mark Twain. Control of the river was a key factor in determining who won the U.S. Civil War. For much of the nation’s early history, the Mississippi was as important to the USA as the Nile to Egyptians. It stretches from its headwaters in icy Lake Itasca in Northwestern Minnesota and flows more than 3,700 kilometers (2,300 miles) to the Gulf of Mexico, fed by dozens of tributaries along the way. A trip down the Great River Road, a series of thoroughfares stretching from Minnesota to Louisiana, is an opportunity to experience a wide range of American regional culture and the eclectic diversity of its people. To understand the river is to understand the USA. Plan your next Great River Road trip and explore the USA even more.

01
Al fresco dining at night in Minneapolis, Minnesota
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Minneapolis and St. Paul, Minnesota

Begin your trip in Minnesota when you fly into Minneapolis-St Paul International Airport. The modern metropolis of Minneapolis was the jumping off point for westward expansion and home to grain mills along the Mississippi River banks, remnants of which you can see today. The friendly city was also the lifelong home to one of the USA’s most innovative performers: Prince. The First Avenue Club is the venue where Prince began performing and would continue to play throughout his career. Nearby in Bloomington, the Mall of America – the second largest shopping mall in the United States – offers 500 retail stores, rollercoaster rides, luxury hotels and a water park. In the summer, catch a Minnesota Twins game at Target Field, consistently ranked as one of the best ballparks in Major League Baseball.

385 km
5 hours by car
02
Great River Road Ship's Wheel Sign in Potosi, Wisconsin
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Potosi, Wisconsin

After Minneapolis drive south through Minnesota to the quaint town of Potosi. The National Brewery Museum in Potosi, Wisconsin merges the transportation and commerce that the Mississippi is known for with Wisconsin’s storied brewing heritage. The museum explores the history of Midwestern brewing and offers tours of the facility where its beer is made. The museum also has a dedicated section on the history of the Great River Road. After the tour, cross the border into Iowa at Dubuque, which sits as the crossroads of Iowa, Illinois and Wisconsin. There you can visit the National Mississippi River Museum & Aquarium and stretch your legs on a walk in Eagle Point Park, taking in the panoramic river views.

158 km
2 hours by car
03
Steamboat on the Mississippi River in LeClaire, Iowa
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LeClaire, Iowa

The picturesque town of LeClaire, Iowa is the perfect place to take a ride on an iconic Mississippi River riverboat complete with a red paddle wheel that will take you back in time. The cruises are 90 minutes long and discuss the importance of the Mississippi River. After, stop at the not-to-be-missed Buffalo Bill Museum, commemorating LeClaire’s most famous native son William “Buffalo Bill” Cody and his Wild West Show. For birdwatchers, LeClaire has some of the best viewing areas for migratory bald eagles. Fans of reality television will not want to miss Antique Archeology, the antique shop featured on the TV show American Pickers.  

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293 km
3 hours by car
04
Red-brick street in Hannibal, Missouri
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Hannibal, Missouri

No trip on the Great River Road would be complete without a visit to the hometown of one of the USA’s most beloved authors, Mark Twain. His boyhood home and museum are situated in a recreated town animated by historical actors and interpreters. It is a charming and immersive introduction to the life and times of one of the world’s greatest literary icons. If this isn’t enough Americana for you, the museum also features 15 original Norman Rockwell oil paintings.

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189 km
2 hours by car
05
Cardinals Major League Baseball game in St. Louis, Missouri
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St. Louis, Missouri

As you drive into St. Louis, Missouri, the state’s second largest city, you will see the famous Gateway Arch. Marvel at the massive landmark from below, then take the elevator up to the top for panoramic views of the city. Take a break from driving with a stroll through the sprawling Forest Park, where you’ll find the St. Louis Zoo, Missouri History Museum and more. Afterward, head to Busch Stadium, home to the St. Louis Cardinals, to catch a baseball game right in the center of town.

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456 km
5 hours by car
06
Beale Street lights at night in Memphis, Tennessee
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Andrew McMurtrie/Tennessee Photographic Services

Memphis, Tennessee

Cruise through St. Louis into Memphis, Tennessee known as the “home of the Blues.” Catch some of the city’s favorite tunes along Beale Street and learn about music history at Memphis Rock ‘n’ Soul Museum. Make sure to track down some authentic Memphis barbecue at spots like Central BBQ or Charlie Vergos’ Rendezvous. The two major attractions in Memphis are Graceland and The National Civil Rights Museum. Graceland is the iconic estate of the King of Rock ‘n Roll Elvis Presley. With its shag rugs, mountains of gold records and two private planes, the Lisa Marie and Hound Dog II, Graceland is the ultimate monument to Elvis’ life and aesthetic. The National Civil Rights Museum is housed in the former Lorraine Motel, the site of the Rev. Dr. Martin Luther King’s assassination in 1968. After paying tribute to Dr. King and The King, stop by the Peabody Hotel for a drink and one of Memphis’ quirkiest and most beloved traditions: the duck walk.

489 km
5 hours by car
07
Streetlit roadway by the Mississippi River in Natchez, Mississippi
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Natchez, Mississippi

No trip through the Deep South would be complete without a visit to a stately, antebellum Southern mansion, and Natchez, Mississippi offers enchanting options. Longwood, a one-of-a-kind octagonal mansion with an onion dome, was built in 1860, though the interior was never completed due to the outbreak of the Civil War. A great place to eat nearby is the Carriage House, an eatery in another 19th century mansion serving Southern staples and a very popular brunch.

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284 km
3 hours by car
08
City street in the French Quarter in New Orleans, Louisiana
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New Orleans, Louisiana

End your study of the Great River Road in New Orleans, a Louisiana city that just bursts with music. Walk around the French Quarter to take in the unique buildings and narrow streets with art galleries, eateries and more. Take in the action on Bourbon Street in the French Quarter, where revelers party in the street; or opt for a more low-key night taking in jazz and other local beats on Frenchmen Street. Once your journey is complete, head to Louis Armstrong New Orleans International Airport to travel home.